Application of Selected Ion Monitoring-Gas Chromatography Mass Spectrometry (SIM-GCMS) for Quantification of Poly Aromatic Hydro Carbons in Surface Water from Sarawak, Mambong River (Malaysia)

Determination of 1,4-Dioxane in Drinking Water by Gas Chromatography/Mass Spectrometry (GC/MS) with Selected Ion Monitoring (SIM)

Introduction 1,4-Dioxane is used mainly as a stabilizer for 1,1,1-trichloroethane for transport in aluminum containers. It is an irritant to eyes and respiratory system and suspected of causing damage to nervous system, liver, and kidneys.1 In 2008, testing sponsored by the U.S. Organic Consumers Association found dioxane in almost half of tested organic personal-care products.1 Of the total 1....

Determination of testosterone in human hair by gas chromatography-selected ion monitoring mass spectrometry.

A method for the determination of testosterone in human hair by gas chromatography-mass spectrometry using d3-testosterone as internal standard is described. Our method consisted of alkaline digestion, fast liquid-liquid extraction, LH-20 chromatography and derivatization with heptafluorobutyric anhydride. Quantification was achieved by selected ion monitoring of m/z 680 (testosterone) and m/z ...

Determination of corticosterone in rat and mouse plasma by gas chromatography-selected ion monitoring mass spectrometry.

A simple, highly sensitive and specific method based on gas-chromatography-selected ion monitoring (SIM) mass spectrometry has been developed for the quantitation of corticosterone in rat and mouse plasma. After extraction of the plasma with ethyl acetate, the residue was trimethy-silylated with pentafluorobenzyl hydroxylamine-trimethylsilyl (PFBO-TMS). Detection of the derivatives was accompli...

Determination of plasma trimetrexate levels using gas chromatography-mass spectrometry with selected-ion monitoring.

Trimetrexate is a potent inhibitor of dihydrofolate reductase and has demonstrated significant antitumor activity against murine and human cell lines both in vitro and against several murine transplanted tumors. The importance of antifolate concentration and exposure time in determining toxic and therapeutic effects necessitates an assay of suitable sensitivity, accuracy and specificity for inv...

Determination of 1,4-dioxane in Drinking Water by Solid Phase Extraction (spe) and Gas Chromatography/mass Spectrometry (gc/ms) with Selected Ion Monitoring (sim)